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dc.creatorCiani, Elena
dc.creatorMastrangelo, Salvatore
dc.creatorDa Silva, Anne
dc.creatorMarroni, Fabio
dc.creatorFerenčaković5, Maja
dc.creatorAjmone‑Marsan, Paolo A
dc.creatorBaird7, Hayley
dc.creatorBarbato, Mario
dc.creatorColli6, Licia
dc.creatorDelvento, Chiara
dc.creatorDovenski, Toni
dc.creatorGorjanc, Gregor
dc.creatorJ. G. Hall, Stephen
dc.creatorHoda, Anila
dc.creatorHua Li, Meng
dc.creatorMarković, Božidarka
dc.creatorMcEwan, John
dc.creatorH. Moradi, Mohammad
dc.creatorRuiz‑Larrañaga, Otsanda
dc.creatorRužić-Muslić, Dragana
dc.creatorŠalamon, Dragica
dc.creatorSimčič, Mojca
dc.creatorStepanek, Ondrej
dc.creatorConsortium, Econogene
dc.creatorConsortium, Sheephapmap
dc.creatorCurik, Ino
dc.creatorCubric‑Curik, Vlatka
dc.creatorA. Lenstra, Johannes
dc.description.abstractBackground: In the Neolithic, domestic sheep migrated into Europe and subsequently spread in westerly and northwesterly directions. Reconstruction of these migrations and subsequent genetic events requires a more detailed characterization of the current phylogeographic differentiation. Results: We collected 50 K single nucleotide polymorphism (SNP) profiles of Balkan sheep that are currently found near the major Neolithic point of entry into Europe, and combined these data with published genotypes from southwest- Asian, Mediterranean, central-European and north-European sheep and from Asian and European mouflons. We detected clines, ancestral components and admixture by using variants of common analysis tools: geography-informative supervised principal component analysis (PCA), breed-specific admixture analysis, across-breed f4 profiles and phylogenetic analysis of regional pools of breeds. The regional Balkan sheep populations exhibit considerable genetic overlap, but are clearly distinct from the breeds in surrounding regions. The Asian mouflon did not influence the differentiation of the European domestic sheep and is only distantly related to present-day sheep, including those from Iran where the mouflons were sampled. We demonstrate the occurrence, from southeast to northwest Europe, of a continuously increasing ancestral component of up to 20% contributed by the European mouflon, which is assumed to descend from the original Neolithic domesticates. The overall patterns indicate that the Balkan region and Italy served as post-domestication migration hubs, from which wool sheep reached Spain and north Italy with subsequent migrations northwards. The documented dispersal of Tarentine wool sheep during the Roman period may have been part of this process. Our results also reproduce the documented 18th century admixture of Spanish Merino sheep into several central-European
dc.relationProject ANAGRAMS-IP-2018-01-8708 ,projects ECONOGENE QLK5–CT2001–02461sr
dc.relationECONOGENE QLK5–CT2001–02461sr
dc.relationGlobalDiv AgriGen Res 870/2004sr
dc.sourceGenetic Selection Evolutionsr
dc.subjectsheep diversity Balkan breedssr
dc.subjectsheep diversity Balkan breedssr
dc.titleOn the origin of European sheep as revealed by the diversity of the Balkan breeds and by optimizing population-genetic analysis toolssr
dcterms.abstractРужић‑Муслић, Драгана; Шаламон, Драгица; Симчич, Мојца; Делвенто, Цхиара; Довенски, Тони; Степанек, Ондреј; Цонсортиум, Ецоногене; Цубриц‑Цурик, Влатка; A. Ленстра, Јоханнес; Цонсортиум, Схеепхапмап; Цурик, Ино; Маррони, Фабио; Ференчаковић5, Маја; Aјмоне‑Марсан, Паоло A; Баирд7, Хаyлеy; Барбато, Марио; Цолли6, Лициа; Циани, Елена; Мастрангело, Салваторе; Да Силва, Aнне; Горјанц, Грегор; Ј. Г. Халл, Степхен; Хода, Aнила; Хуа Ли, Менг; Марковић, Божидарка; МцЕwан, Јохн; Х. Моради, Мохаммад; Руиз‑Ларраñага, Отсанда;

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