TY  - JOUR
AU  - Šojat, Dunja
AU  - Volarić, Mile
AU  - Keškić, Tanja
AU  - Volarić, Nikola
AU  - Cerovečki, Venija
AU  - Trtica Majnarić, Ljiljana
PY  - 2024-03-21
UR  - http://r.istocar.bg.ac.rs/handle/123456789/991
AB  - The spectrum, intensity, and overlap of symptoms between functional gastrointestinal
disorders (FGIDs) and other gastrointestinal disorders characterize patients with FGIDs, who are
incredibly different in their backgrounds. An additional challenge with regard to the diagnosis
of FGID and the applicability of a given treatment is the ongoing expansion of the risk factors
believed to be connected to these disorders. Many cytokines and inflammatory cells have been
found to cause the continuous existence of a low level of inflammation, which is thought to be a
basic pathophysiological process. The idea of the gut–brain axis has been created to offer a basic
framework for the complex interactions that occur between the nervous system and the intestinal
functions, including the involvement of gut bacteria. In this review paper, we intend to promote the
hypothesis that FGIDs should be seen through the perspective of the network of the neuroendocrine,
immunological, metabolic, and microbiome pathways. This hypothesis arises from an increased
understanding of chronic inflammation as a systemic disorder, that is omnipresent in chronic health
conditions. A better understanding of inflammation’s role in the pathogenesis of FGIDs can be
achieved by clustering markers of inflammation with data indicating symptoms, comorbidities,
and psycho-social factors. Finding subclasses among related entities of FGIDs may reduce patient
heterogeneity and help clarify the pathophysiology of this disease to allow for better treatment.
PB  - MDPI
T2  - Biomedicines
T1  - Putting Functional Gastrointestinal Disorders within the Spectrum of Inflammatory Disorders Can Improve Classification and Diagnostics of These Disorders
VL  - 12
IS  - 3
SP  - 702
DO  - 10.3390/biomedicines12030702
ER  - 

@article{
author = "Šojat, Dunja and Volarić, Mile and Keškić, Tanja and Volarić, Nikola and Cerovečki, Venija and Trtica Majnarić, Ljiljana",
year = "2024-03-21",
abstract = "The spectrum, intensity, and overlap of symptoms between functional gastrointestinal
disorders (FGIDs) and other gastrointestinal disorders characterize patients with FGIDs, who are
incredibly different in their backgrounds. An additional challenge with regard to the diagnosis
of FGID and the applicability of a given treatment is the ongoing expansion of the risk factors
believed to be connected to these disorders. Many cytokines and inflammatory cells have been
found to cause the continuous existence of a low level of inflammation, which is thought to be a
basic pathophysiological process. The idea of the gut–brain axis has been created to offer a basic
framework for the complex interactions that occur between the nervous system and the intestinal
functions, including the involvement of gut bacteria. In this review paper, we intend to promote the
hypothesis that FGIDs should be seen through the perspective of the network of the neuroendocrine,
immunological, metabolic, and microbiome pathways. This hypothesis arises from an increased
understanding of chronic inflammation as a systemic disorder, that is omnipresent in chronic health
conditions. A better understanding of inflammation’s role in the pathogenesis of FGIDs can be
achieved by clustering markers of inflammation with data indicating symptoms, comorbidities,
and psycho-social factors. Finding subclasses among related entities of FGIDs may reduce patient
heterogeneity and help clarify the pathophysiology of this disease to allow for better treatment.",
publisher = "MDPI",
journal = "Biomedicines",
title = "Putting Functional Gastrointestinal Disorders within the Spectrum of Inflammatory Disorders Can Improve Classification and Diagnostics of These Disorders",
volume = "12",
number = "3",
pages = "702",
doi = "10.3390/biomedicines12030702"
}

Šojat, D., Volarić, M., Keškić, T., Volarić, N., Cerovečki, V.,& Trtica Majnarić, L.. (2024-03-21). Putting Functional Gastrointestinal Disorders within the Spectrum of Inflammatory Disorders Can Improve Classification and Diagnostics of These Disorders. in Biomedicines
MDPI., 12(3), 702.
https://doi.org/10.3390/biomedicines12030702

Šojat D, Volarić M, Keškić T, Volarić N, Cerovečki V, Trtica Majnarić L. Putting Functional Gastrointestinal Disorders within the Spectrum of Inflammatory Disorders Can Improve Classification and Diagnostics of These Disorders. in Biomedicines. 2024;12(3):702.
doi:10.3390/biomedicines12030702 .

Šojat, Dunja, Volarić, Mile, Keškić, Tanja, Volarić, Nikola, Cerovečki, Venija, Trtica Majnarić, Ljiljana, "Putting Functional Gastrointestinal Disorders within the Spectrum of Inflammatory Disorders Can Improve Classification and Diagnostics of These Disorders" in Biomedicines, 12, no. 3 (2024-03-21):702,
https://doi.org/10.3390/biomedicines12030702 . .