TY  - JOUR
AU  - Ciani, Elena
AU  - Mastrangelo, Salvatore
AU  - Da Silva, Anne
AU  - Marroni, Fabio
AU  - Ferenčaković5, Maja
AU  - Ajmone‑Marsan, Paolo A
AU  - Baird7, Hayley
AU  - Barbato, Mario
AU  - Colli6, Licia
AU  - Delvento, Chiara
AU  - Dovenski, Toni
AU  - Gorjanc, Gregor
AU  - J. G. Hall, Stephen
AU  - Hoda, Anila
AU  - Hua Li, Meng
AU  - Marković, Božidarka
AU  - McEwan, John
AU  - H. Moradi, Mohammad
AU  - Ruiz‑Larrañaga, Otsanda
AU  - Ružić-Muslić, Dragana
AU  - Šalamon, Dragica
AU  - Simčič, Mojca
AU  - Stepanek, Ondrej
AU  - Consortium, Econogene
AU  - Consortium, Sheephapmap
AU  - Curik, Ino
AU  - Cubric‑Curik, Vlatka
AU  - A. Lenstra, Johannes
PY  - 2020-05-14
UR  - http://r.istocar.bg.ac.rs/handle/123456789/844
AB  - Background: In the Neolithic, domestic sheep migrated into Europe and subsequently spread in westerly and
northwesterly directions. Reconstruction of these migrations and subsequent genetic events requires a more detailed
characterization of the current phylogeographic differentiation.
Results: We collected 50 K single nucleotide polymorphism (SNP) profiles of Balkan sheep that are currently found
near the major Neolithic point of entry into Europe, and combined these data with published genotypes from southwest-
Asian, Mediterranean, central-European and north-European sheep and from Asian and European mouflons. We
detected clines, ancestral components and admixture by using variants of common analysis tools: geography-informative
supervised principal component analysis (PCA), breed-specific admixture analysis, across-breed f4 profiles and
phylogenetic analysis of regional pools of breeds. The regional Balkan sheep populations exhibit considerable genetic
overlap, but are clearly distinct from the breeds in surrounding regions. The Asian mouflon did not influence the differentiation
of the European domestic sheep and is only distantly related to present-day sheep, including those from
Iran where the mouflons were sampled. We demonstrate the occurrence, from southeast to northwest Europe, of a
continuously increasing ancestral component of up to 20% contributed by the European mouflon, which is assumed
to descend from the original Neolithic domesticates. The overall patterns indicate that the Balkan region and Italy
served as post-domestication migration hubs, from which wool sheep reached Spain and north Italy with subsequent
migrations northwards. The documented dispersal of Tarentine wool sheep during the Roman period may have been
part of this process. Our results also reproduce the documented 18th century admixture of Spanish Merino sheep into
several central-European breeds.
T2  - Genetic Selection Evolution
T1  - On the origin of European sheep as revealed by the diversity of the Balkan breeds and by optimizing population-genetic analysis tools
VL  - 52:25
DO  - https://doi.org/10.1186/s12711-020-00545-7
ER  - 

@article{
author = "Ciani, Elena and Mastrangelo, Salvatore and Da Silva, Anne and Marroni, Fabio and Ferenčaković5, Maja and Ajmone‑Marsan, Paolo A and Baird7, Hayley and Barbato, Mario and Colli6, Licia and Delvento, Chiara and Dovenski, Toni and Gorjanc, Gregor and J. G. Hall, Stephen and Hoda, Anila and Hua Li, Meng and Marković, Božidarka and McEwan, John and H. Moradi, Mohammad and Ruiz‑Larrañaga, Otsanda and Ružić-Muslić, Dragana and Šalamon, Dragica and Simčič, Mojca and Stepanek, Ondrej and Consortium, Econogene and Consortium, Sheephapmap and Curik, Ino and Cubric‑Curik, Vlatka and A. Lenstra, Johannes",
year = "2020-05-14",
abstract = "Background: In the Neolithic, domestic sheep migrated into Europe and subsequently spread in westerly and
northwesterly directions. Reconstruction of these migrations and subsequent genetic events requires a more detailed
characterization of the current phylogeographic differentiation.
Results: We collected 50 K single nucleotide polymorphism (SNP) profiles of Balkan sheep that are currently found
near the major Neolithic point of entry into Europe, and combined these data with published genotypes from southwest-
Asian, Mediterranean, central-European and north-European sheep and from Asian and European mouflons. We
detected clines, ancestral components and admixture by using variants of common analysis tools: geography-informative
supervised principal component analysis (PCA), breed-specific admixture analysis, across-breed f4 profiles and
phylogenetic analysis of regional pools of breeds. The regional Balkan sheep populations exhibit considerable genetic
overlap, but are clearly distinct from the breeds in surrounding regions. The Asian mouflon did not influence the differentiation
of the European domestic sheep and is only distantly related to present-day sheep, including those from
Iran where the mouflons were sampled. We demonstrate the occurrence, from southeast to northwest Europe, of a
continuously increasing ancestral component of up to 20% contributed by the European mouflon, which is assumed
to descend from the original Neolithic domesticates. The overall patterns indicate that the Balkan region and Italy
served as post-domestication migration hubs, from which wool sheep reached Spain and north Italy with subsequent
migrations northwards. The documented dispersal of Tarentine wool sheep during the Roman period may have been
part of this process. Our results also reproduce the documented 18th century admixture of Spanish Merino sheep into
several central-European breeds.",
journal = "Genetic Selection Evolution",
title = "On the origin of European sheep as revealed by the diversity of the Balkan breeds and by optimizing population-genetic analysis tools",
volume = "52:25",
doi = "https://doi.org/10.1186/s12711-020-00545-7"
}

Ciani, E., Mastrangelo, S., Da Silva, A., Marroni, F., Ferenčaković5, M., Ajmone‑Marsan, P. A., Baird7, H., Barbato, M., Colli6, L., Delvento, C., Dovenski, T., Gorjanc, G., J. G. Hall, S., Hoda, A., Hua Li, M., Marković, B., McEwan, J., H. Moradi, M., Ruiz‑Larrañaga, O., Ružić-Muslić, D., Šalamon, D., Simčič, M., Stepanek, O., Consortium, E., Consortium, S., Curik, I., Cubric‑Curik, V.,& A. Lenstra, J.. (2020-05-14). On the origin of European sheep as revealed by the diversity of the Balkan breeds and by optimizing population-genetic analysis tools. in Genetic Selection Evolution, 52:25.
https://doi.org/https://doi.org/10.1186/s12711-020-00545-7

Ciani E, Mastrangelo S, Da Silva A, Marroni F, Ferenčaković5 M, Ajmone‑Marsan PA, Baird7 H, Barbato M, Colli6 L, Delvento C, Dovenski T, Gorjanc G, J. G. Hall S, Hoda A, Hua Li M, Marković B, McEwan J, H. Moradi M, Ruiz‑Larrañaga O, Ružić-Muslić D, Šalamon D, Simčič M, Stepanek O, Consortium E, Consortium S, Curik I, Cubric‑Curik V, A. Lenstra J. On the origin of European sheep as revealed by the diversity of the Balkan breeds and by optimizing population-genetic analysis tools. in Genetic Selection Evolution. 2020;52:25.
doi:https://doi.org/10.1186/s12711-020-00545-7 .

Ciani, Elena, Mastrangelo, Salvatore, Da Silva, Anne, Marroni, Fabio, Ferenčaković5, Maja, Ajmone‑Marsan, Paolo A, Baird7, Hayley, Barbato, Mario, Colli6, Licia, Delvento, Chiara, Dovenski, Toni, Gorjanc, Gregor, J. G. Hall, Stephen, Hoda, Anila, Hua Li, Meng, Marković, Božidarka, McEwan, John, H. Moradi, Mohammad, Ruiz‑Larrañaga, Otsanda, Ružić-Muslić, Dragana, Šalamon, Dragica, Simčič, Mojca, Stepanek, Ondrej, Consortium, Econogene, Consortium, Sheephapmap, Curik, Ino, Cubric‑Curik, Vlatka, A. Lenstra, Johannes, "On the origin of European sheep as revealed by the diversity of the Balkan breeds and by optimizing population-genetic analysis tools" in Genetic Selection Evolution, 52:25 (2020-05-14),
https://doi.org/https://doi.org/10.1186/s12711-020-00545-7 . .